Exploring the Gut-Brain Axis Role in Neuroinflammation and Lower Back Pain
- moveflowwellness
- Jan 24
- 3 min read
Updated: Jan 27
Muscle tension and lower back pain affect millions worldwide, often leading to chronic discomfort and reduced quality of life. While physical strain and injury are common causes, recent research points to deeper biological connections involving the gut brain axis and neuroinflammation. Understanding these links can open new paths for managing pain and improving overall health.

How Muscle Tension Contributes to Lower Back Pain
Muscle tension occurs when muscles remain contracted for extended periods, leading to stiffness, discomfort, and pain. In the lower back, this tension can compress nerves and reduce blood flow, worsening pain symptoms. Common triggers include poor posture, repetitive movements, stress, and lack of physical activity.
Postural habits like slouching or sitting for long hours increase strain on lower back muscles.
Stress causes the body to hold tension unconsciously, especially in the back and shoulders.
Physical inactivity weakens muscles, making them more prone to tightness and injury.
Muscle tension is not just a mechanical issue; it interacts with the nervous system and inflammatory processes, which can amplify pain signals.
The Gut Brain Axis and Its Role in Pain Perception
The gut brain axis refers to the two-way communication network between the gastrointestinal system and the brain. This connection involves neural, hormonal, and immune pathways that influence mood, pain perception, and inflammation.
The gut microbiome produces neurotransmitters and metabolites that affect brain function.
Signals from the gut can modulate the central nervous system’s response to pain.
Disruptions in gut health, such as imbalances in gut bacteria, may increase sensitivity to pain.
For example, people with irritable bowel syndrome (IBS) often report higher rates of chronic pain, including lower back pain. This suggests that gut health can influence muscle tension and pain through the gut brain axis.
Neuroinflammation as a Link Between Gut Health and Muscle Pain
Neuroinflammation is the activation of the immune system within the nervous system, often leading to increased pain sensitivity. Chronic low-grade inflammation in the nervous system can result from gut dysbiosis (microbial imbalance) and contribute to persistent muscle tension and pain.
Inflammatory molecules from the gut can cross into the bloodstream and affect the brain and spinal cord.
This inflammation sensitizes nerve pathways, making muscles feel more tense and painful.
Neuroinflammation may explain why some people experience pain without obvious physical injury.
Research shows that reducing neuroinflammation through diet, lifestyle changes, and targeted therapies can help relieve chronic pain conditions.

Habits That Influence the Gut Brain Axis and Muscle Tension
Certain daily habits can either worsen or improve the interaction between the gut brain axis, neuroinflammation, and muscle tension. Adjusting these habits can support pain management and overall well-being.
Diet: Eating a balanced diet rich in fiber, probiotics, and anti-inflammatory foods supports gut health and reduces inflammation.
Physical activity: Regular, gentle exercise like walking, yoga, or stretching helps maintain muscle flexibility and reduces tension.
Stress management: Techniques such as meditation, deep breathing, and adequate sleep lower stress hormones that contribute to muscle tightness.
Hydration: Staying well-hydrated supports muscle function and reduces cramping.
Avoiding prolonged sitting: Taking breaks to move and stretch prevents muscle stiffness and supports circulation.
By focusing on these habits, individuals can positively influence their gut brain axis and reduce neuroinflammation, which may lessen muscle tension and lower back pain.
Practical Steps to Address Muscle Tension and Lower Back Pain
Understanding the biological connections allows for a more comprehensive approach to managing pain:
Improve gut health through probiotic-rich foods like yogurt, kefir, and fermented vegetables.
Incorporate anti-inflammatory foods such as fatty fish, nuts, and leafy greens.
Practice regular stretching and strengthening exercises targeting the lower back and core muscles.
Use mindfulness and relaxation techniques to reduce stress-related muscle tension.
Consult healthcare providers for personalized advice, especially if pain persists or worsens.
These steps work together to reduce neuroinflammation and support the gut brain axis, helping to break the cycle of muscle tension and pain.
Muscle tension and lower back pain are complex issues influenced by more than just physical strain. The gut brain axis and neuroinflammation play significant roles in how pain develops and persists. By adopting habits that support gut health and reduce inflammation, individuals can find new ways to manage pain and improve their quality of life.



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